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Pharmaceutical Grade Water Treatment Solutions

Meeting all stringent enterprise requirements for equipment quality and operational efficiency

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Flexible design & cost optimization

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GMP documentation support

Committed to GMP-EU standard quality

WHO WE ARE

NGO International., LTD is an environmental solution provider, bringing together outstanding and dynamic young engineers with highly experienced experts from China, India, and Vietnam. We possess outstanding strengths in applying advanced technologies in water supply treatment, purified water, ultrapure water, wastewater treatment, exhaust gas treatment, reuse and recirculation, and saline water treatment, backed by 10 years of experience in Vietnam.

Possessing a smart management system and clear, professional QC procedures.

PROUD THAT 100% OF PROJECTS ARE COMPLETED WITH THE RIGHT QUALITY & ACCEPTED BY CUSTOMERS

Tìm hiểu

TYPICAL PARTNERS AND PROJECTS

516

CUSTOMERS

10

YEARS OF EXPERIENCE

8

COUNTRIES

7

PATENTS

COMMON ERRORS IN PHARMACEUTICAL PURIFIED WATER SYSTEMS

1. Fluctuations in feed water quality

The feed water source in Vietnam is becoming increasingly polluted, and the characteristics of the feed water change over time. The purified water production line must be capable of handling fluctuations in inlet water quality.

2. High investment and operating costs

“Over-engineering” should be avoided, as it makes the system more expensive and harder to maintain and service.

Sometimes systems are designed much more complexly than necessary for the purpose of TOC control (including treated water TOC and CIP line TOC).
Compliance with EU GMP Annex 11 and FDA 21 CFR Part 11 is sometimes confused with the requirement that SCADA is mandatory for all systems.

3. Improper design causing secondary contamination

Improper design of purified water storage tanks will lead to an increase in the TOC index in the water: usually due to inappropriate material selection and ventilation design.

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NGO’S ADVANTAGES

CAPABLE OF PERFORMING FAT (FACTORY ACCEPTANCE TEST) FOR THE ENTIRE SYSTEM UPON REQUEST

DESIGNING A 2-WAY WATER SUPPLY SYSTEM FOR PROJECTS REQUIRING 24/7 OPERATION WITH ZERO DOWNTIME

COMMITMENT TO THE MOST OPTIMAL INVESTMENT COST

NGO’S GMP-EU STANDARD WATER TREATMENT PROCESS

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PURIFIED WATER TREATMENT SYSTEM

GMP – EU Standard compliant
GMP – WHO Standard compliant
FDA Standard compliant

PURE STEAM TREATMENT SYSTEM

GMP – EU Standard compliant
GMP – WHO Standard compliant
FDA Standard compliant

ION EXCHANGE MEMBRANE SYSTEM

Desalination and pharmaceutical ingredient recovery.

STAGE 1: PRE-TREATMENT – THE FOUNDATION TO PROTECT THE ENTIRE SYSTEM

This is an important step to treat coarse impurities and chemicals in the source water, protecting the “heart” of the system, the RO membrane, from clogging and damage.

Multi-media filtration: Removes suspended solids, sediment, and turbidity.
Activated carbon: Thoroughly adsorbs free Chlorine – an oxidizing agent that destroys the RO membrane structure. It also removes color, odor, and organic compounds.
Water softening: Removes Calcium (Ca²⁺) and Magnesium (Mg²⁺) ions – the main causes of scaling on the RO membrane surface, helping the system operate stably and extending its lifespan.

STAGE 2: FINE TREATMENT – THE HEART OF THE SYSTEM

RO Reverse Osmosis System (Single or Double Pass): The pre-treated water will be pumped at high pressure through microscopic RO membranes. This technology can remove up to 99.9% of dissolved ions, bacteria, and viruses, producing high-purity water that meets most PW requirements. We prioritize using a Double Pass RO system to ensure the highest stability in output water quality.

STAGE 3: DEEP DEMINERALIZATION – ACHIEVING ABSOLUTE PURITY

Although the RO-treated water is very clean, to achieve the extremely low electrical conductivity required by GMP-EU standards (< 1.3 µS/cm), a final deionization step is necessary.

EDI (Electrodeionization) Technology: This is the most advanced and popular technology today. EDI uses an electrical current to continuously remove remaining ions, helping the water achieve a very high level of purity.

Advantages: Automatic and continuous operation, highly stable water quality, and absolutely no chemical regeneration (acid/caustic) required, making it safe for production and environmentally friendly.

(Alternative option) Mixed-bed Ion Exchange: A traditional technology that can still be used to optimize initial investment costs, but requires stopping the system for chemical regeneration.

STAGE 4: STERILIZATION ASSURANCE AND DISTRIBUTION

UV Sterilization: The treated water is irradiated with UV light to destroy the DNA structure of any remaining microorganisms, preventing their growth.
Microfiltration (0.2 µm): This is the final safety “checkpoint” before entering the storage tank, completely removing bacterial carcasses and the smallest microparticles.
Storage and Recirculation Distribution: Purified water is stored in 316L sanitary stainless steel tanks and continuously circulated in a closed loop to points of use. This process ensures consistent water quality at all usage points and prevents re-contamination.

ADVANCED STEP (Optional): DISTILLATION FOR WATER FOR INJECTION (WFI)

For production lines of injectable drugs and vaccines, purified water (PW) will be passed through a Multi-Effect Distillation System to thoroughly eliminate bacterial endotoxins (pyrogens/endotoxins), producing WFI that meets the highest Pharmacopoeia standards.

EQUIPMENT MANUFACTURING WORKSHOP

AUTOMATION SYSTEM

1. Multi-level electrical control system

HMI Interface + PLC Controller
Using S7 Smart, 1200, 1500 series
COMOS integrated control system

2. Superior remote control system

Remote control and data management
Remote debugging and program recovery
Abnormal alerts and remote diagnostics

3. After-sales application (APP) system

Big data

EQUIPMENT VALIDATION DOCUMENTATION SYSTEM

We discuss risk management with customers prior to quoting and can assist in preparing URS (User Requirement Specifications) complying with the latest GMP version; establish QPP and project schedules, and hold a kick-off meeting after receiving an order; provide design documents for design qualification to resolve major discrepancies early on; execute all testing activities according to the internal quality management system during the manufacturing phase, and maintain detailed records and reports